Hydrochloric Acid → HCID 17430480, compound

HRID 1868004Notes

Reaction equation

HRID 1868004 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.Cl.[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22](Cl)(=[O:24])=[O:23].C(N(C(C)C)CC)(C)C>ClCCl>[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22]([N:11]1[CH2:12][CH2:13][N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[CH2:9][CH2:10]1)(=[O:24])=[O:23]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 705291-(2-Fluorophenyl)piperazineHCID 761872-Chlorobenzenesulfonyl chlorideHCID 81531Diisopropylethylamine

Product 1

HCID 17430480HCID 17430480, compoundYield 75.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Sulfonylation of 1-(2-fluorophenyl)piperazine.HCl (325 mg, 1.5 mmol) with 2-chlorobenzene-1-sulfonyl chloride (316.6 mg, 1.5 mmol) was carried out according to a similar procedure described for step 1A using anhydrous dichloromethane (3 mL) as solvent and diisopropylethylamine (0.575 mL, 3.3 mmol) as base. 1-[(2-chlorophenyl)sulfonyl]-4-(2-fluorophenyl)piperazine was obtained in 75.5% yield (402 mg) as white solid.

Sources & evidence

ORD record
ord-6d66c529fc154c0388fc61cd3901575c
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

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