Diethyl Malonate → HCID 67099724, compound

Temperature

0 °C

A solution of 2-(2-chlorophenyl)-2-methylpropanoic acid (2.55 g, 12.8 mmol) in thionyl chloride (50.0 mL, 685 mmol) was heated at 95° C. for 2 hours. The solution was concentrated in vacuo, azeotroped using toluene (2×100 mL), and dried in vacuo to give the crude acid chloride. A mixture of diethyl malonate (1.94 mL, 12.8 mmol) and MgCl2 (1.22 g, 12.8 mmol) in ACN (50 mL) was cooled to 0° C. TEA (3.75 mL, 27.0 mmol) was added slowly, and the mixture was stirred at 25° C. for 2 hours. A solution of the acid chloride in ACN (50 mL) was added, and the mixture was heated at 50° C. for 2 days. The solution was diluted with 10% HCl (aq) (200 mL) and extracted with EtOAc (3×100 mL). The combined organic layers were washed with 2N NaOH (aq) (3×200 mL) and then with brine (75 mL). The organic layer was dried over MgSO4, concentrated, and purified by flash column chromatography (silica, 0-100% DCM in hexane) to give diethyl 2-(2-(2-chlorophenyl)-2-methylpropanoyl)malonate (3.25 g). MS m/e=341 (M+H)+.

1. concentrationThe solution was concentrated in vacuo
2. customazeotroped
3. customdried in vacuo
4. customto give the crude acid chloride
5. temperaturethe mixture was heated at 50° C. for 2 days
6. extractionextracted with EtOAc (3×100 mL)
7. washThe combined organic layers were washed with 2N NaOH (aq) (3×200 mL)
8. dry with materialThe organic layer was dried over MgSO4
9. concentrationconcentrated
10. custompurified by flash column chromatography (silica, 0-100% DCM in hexane)

ORD record

ord-3937f787fe3c412f936301b31dc4a5cc

Source dataset

uspto-grants-2009_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07635715B2