HCID 67099775, compound → HCID 57983400, compound

HRID 1868922Notes

Reaction equation

HRID 1868922 reaction equation
[OH:1][C:2]1[C:3]2[CH:4]=[CH:5][N:6]=[CH:7][C:8]=2[C:9]([CH3:25])([CH3:24])[C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])=[O:13]>C(O)(C(F)(F)F)=O.O>[OH:1][C:2]1[C:3]2[CH:4]=[CH:5][N:6]=[CH:7][C:8]=2[C:9]([CH3:25])([CH3:24])[C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13]

Participants

4

Reactant 1

HCID 67099775HCID 67099775, compound

Product 1

HCID 57983400HCID 57983400, compoundYield 103.4%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of tert-butyl 2-(5-hydroxy-8,8-dimethyl-7-oxo-7,8-dihydroisoquinoline-6-carboxamido)acetate (0.02 g, 0.06 mmol) in 2 mL TFA was stirred at room temperature for 1 hour, M+1=291. The mixture was diluted with 10 mL water. The solution was concentrated and dried to give 0.018 g of the product as a pale yellow solid. MS m/e: (M+H)+ 291.

Workup

  1. concentrationThe solution was concentrated
  2. customdried

Sources & evidence

ORD record
ord-51c733fec92a46d48a5b8d65fef68733
Source dataset
uspto-grants-2009_12
Patent number
US07635715B2

Reaction notes

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