HCID 178451292, compound → HCID 178429099, compound

HRID 1868929Notes

Reaction equation

HRID 1868929 reaction equation
[OH:1][C:2]1[C:3]([CH3:33])([CH3:32])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])=[O:13])=[CH:8][CH:7]=[C:6]([CH2:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH:5]=2>C(O)(C(F)(F)F)=O>[OH:1][C:2]1[C:3]([CH3:33])([CH3:32])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])=[CH:8][CH:7]=[C:6]([CH2:24][CH2:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[CH:5]=2

Participants

3

Reactant 1

HCID 178451292HCID 178451292, compound

Product 1

HCID 178429099HCID 178429099, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Tert-butyl 2-(2-hydroxy-1,1-dimethyl-4-oxo-7-phenethyl-1,4-dihydronaphthalene-3-carboxamido)acetate (130 mg, 289 μmol) was dissolved and stirred in TFA (2 mL) at ambient temperature for 30 minutes. The mixture was then concentrated to give the title compound. MS (ESI) m/z: Calculated; 393.4: Observed; 394.0

Workup

  1. concentrationThe mixture was then concentrated

Sources & evidence

ORD record
ord-8e884c6a37674904b2d38327c3ae3378
Source dataset
uspto-grants-2009_12
Patent number
US07635715B2

Reaction notes

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