反应详情

To a solution of 2-benzyloxycarbonylamino-2-(methyl)-propionic acid (1 g) in tetrahydrofuran (5 mL) was added 1,1′-carbonylbis-1H-imidazole (889 mg), and the mixture was stirred at room temperature for 1 hour. To the reaction mixture was added 2-aminoethanol (0.38 mL), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=20/1) to give 2-[2-benzyloxycarbonylamino-2-(methyl)propionylamino]ethanol (973 mg).

1. stirringthe mixture was stirred at room temperature for 2 hours
2. customThe reaction mixture was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=20/1)