4-Chloro-6,7-dimethoxyquinazoline → HCID 18924998, compound

HRID 1869065Notes

Reaction equation

HRID 1869065 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.Cl.[N:17]([C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1)=[N+:18]=[N-:19]>C(O)(C)C>[ClH:1].[N:17]([C:20]1[CH:26]=[CH:25][C:23]([NH:24][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:22][CH:21]=1)=[N+:18]=[N-:19]

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 162112104-Azidoaniline hydrochloride

Product 1

HCID 18924998HCID 18924998, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4-Chloro-6,7-dimethoxyquinazoline (250 mg, 1.12 mmol) and 4-azidoaniline hydrochloride (200 mg, 1.11 mmol) were refluxed in 10 mL of isopropyl alcohol for 0.5 hour, cooled and filtered to afford solid title product which was washed with 10 mL of isopropyl alcohol and dried in vacuo, at 70° C., 392 mg (98%); mp 200°-205° C. (dec).

Workup

  1. temperaturecooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-879e21c3a3434c21afdefa030a2c84ac
Source dataset
uspto-grants-2009_12
Patent number
USRE041065E1

Reaction notes

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