Methanol → HCID 76696795, compound

HRID 1869146Notes

Reaction equation

HRID 1869146 reaction equation
[Cl:1][C:2]1[CH:22]=[C:21]([O:23][CH2:24][CH:25]=[C:26]([Cl:28])[Cl:27])[CH:20]=[C:19]([Cl:29])[C:3]=1[O:4][CH2:5][C:6](=[CH2:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=O)[CH3:16])=[CH:11][CH:10]=1.Cl.[CH3:31][O:32][NH2:33].CO.C([O-])(=O)C.[Na+]>C(OCC)(=O)C>[CH3:31][O:32][N:33]=[C:15]([C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:7][C:6]([CH2:5][O:4][C:3]2[C:2]([Cl:1])=[CH:22][C:21]([O:23][CH2:24][CH:25]=[C:26]([Cl:27])[Cl:28])=[CH:20][C:19]=2[Cl:29])=[CH2:18])=[CH:14][CH:13]=1)[CH3:16]

Participants

6

Reactant 4

HCID 887MethanolHCID 517045Sodium AcetateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 86613085HCID 86613085, compound

Product 1

HCID 76696795HCID 76696795, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
25 °C

Procedure

286 mg of 1-(4-{2-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxymethyl]-allyloxy}-phenyl)-ethanone and 56 mg of O-methyl-hydroxylamine hydrochloride are introduced into 4 ml of methanol. 55 mg of sodium acetate are then added and the mixture is stirred for 24 hours at 25° C. The reaction mixture is diluted with 12 ml of ethyl acetate and washed twice with water. After concentration of the organic phase and purification over silica gel, the title compound is obtained.

Workup

  1. washwashed twice with water
  2. customAfter concentration of the organic phase and purification over silica gel

Sources & evidence

ORD record
ord-033f553136154cb5ab3f262b6d3d0ca3
Source dataset
uspto-grants-2009_12
Patent number
US07638514B2

Reaction notes

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