反应详情

温度

80 °C

84 mg of potassium tert-butylate and 236 mg of methyltriphenylphosphonium bromide are stirred in 6 ml of toluene for 3 hours at 80° C. 200 mg of 4-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-1-(4-fluoro-phenyl)-butan-1-one in 2 ml of toluene are then added and the mixture is stirred for a further 2 hours at 80° C. The reaction mixture is cooled and filtered and the filtrate is concentrated. After purification over silica gel, the title compound is obtained.

1. temperatureThe reaction mixture is cooled
2. filtrationfiltered
3. concentrationthe filtrate is concentrated
4. customAfter purification over silica gel