4-Chlorobenzaldehyde → HCID 57986041, compound

HRID 1869225Notes

Reaction equation

HRID 1869225 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[CH:10]1([NH2:13])[CH2:12][CH2:11]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[N:13][CH:10]2[CH2:12][CH2:11]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 77264-ChlorobenzaldehydeHCID 69828Cyclopropylamine

Product 1

HCID 57986041HCID 57986041, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Under a nitrogen atmosphere, react 4-chlorobenzaldehyde (14.0 g) and cyclopropylamine (5.7 g) in anhydrous toluene (50 mL) in the presence of molecular sieves for 48 h. Filter the reaction mixture and concentrate the filtrate in vacuo at 60 C to give 4-chlorobenzylidene cyclopropylamine (By as a crystalline solid (15.98 g).

Workup

  1. filtrationFilter the reaction mixture
  2. concentrationconcentrate the filtrate in vacuo at 60 C

Sources & evidence

ORD record
ord-f9340596a5504910b7ebdd39c40975f1
Source dataset
uspto-grants-2009_12
Patent number
US07638526B2

Reaction notes

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