反应详情

温度

50 °C

To a solution of 1.96 g of 5-methylpyrazole-3-carboxylic acid ethyl ester in 40 ml of DMF, 2.64 g of potassium carbonate and 3.53 ml of 3-(tert-butyldimethylsilyloxy)propylbromide were added, and the mixture was stirred at 50° C. for 18 hours. The solvent was evaporated, EtOAc was added to the residue, and the organic layer was washed with water and brine and dried over sodium sulfate. After the evaporation of the solvent, the obtained residue was purified by silica gel column chromatography (eluent: hexane-EtOAc=15:1˜5:1) to obtain 1.39 g of 1-[3-(tert-butyldimethylsilyloxy)propoxyl]-5-methylpyrazole-3-carboxylic acid ethyl ester.

1. customThe solvent was evaporated
2. additionEtOAc was added to the residue
3. washthe organic layer was washed with water and brine
4. dry with materialdried over sodium sulfate
5. customAfter the evaporation of the solvent
6. customthe obtained residue was purified by silica gel column chromatography (eluent: hexane-EtOAc=15:1˜5:1)