反应详情

温度

100 °C

A mixture of 17 (9 g, 0.021 mol), iron (3.65 g, 0.065 mol), and ammonium chloride (2.33 g, 0.043 mol) in isopropanol (200 ml)-water (50 ml) was stirred at 100° C. for 4 h. After cooling, the reaction mixture was filtrated and extracted with CH2Cl2. The combined organic layer was dried by MgSO4 and evaporated to give a residue that was purified by silica gel flash column chromatography (EtOAc:n-hexane=2:3) to afford compound 18, yield 89%.

1. temperatureAfter cooling
2. filtrationthe reaction mixture was filtrated
3. extractionextracted with CH2Cl2
4. dry with materialThe combined organic layer was dried by MgSO4
5. customevaporated
6. customto give a residue that
7. customwas purified by silica gel flash column chromatography (EtOAc:n-hexane=2:3)