Toluene → tert-Butyl 5-bromopyridine-2-carboxylate

A suspension of 5-bromo-2-pyridinecarboxylic acid (may be prepared as described in Description 11) (68.0 g) in tert-butanol (680 ml) and pyridine (190 ml) was stirred vigorously at rt for 0.5 h under argon. 4-Toluenesulfonyl chloride (153.7 g) was then added portionwise over 10 min to give a thick white mixture which gradually dissolved over 2 h to give a dark brown solution. After 4.5 h at rt the reaction mixture was poured slowly with stirring onto a saturated aqueous solution of sodium hydrogen carbonate (136 g) in water (1 l). Stirring was continued for 18 h at rt. The product was then extracted into diethyl ether (2×1 l) and the combined extracts were dried (MgSO4), filtered and concentrated to give a solid. This was treated with toluene (1 l) and the mixture was evaporated to dryness. This was repeated twice more with toluene (2×1 l) to give a pink solid which was dried in vacuo overnight to give 80.0 g of product. Recrystallisation from acetone/water gave the pure title compound (D12) (66.8 g). MS electrospray (+ve ion) 281 (MNa+). 1H NMR δ CDCl3: 8.79 (1H, s), 7.90 (2H, s), 1.64 (9H, s).

1. customto give a thick white mixture which
2. dissolutiongradually dissolved over 2 h
3. customto give a dark brown solution
4. additionAfter 4.5 h at rt the reaction mixture was poured slowly
5. stirringStirring
6. waitwas continued for 18 h at rt
7. extractionThe product was then extracted into diethyl ether (2×1 l)
8. dry with materialthe combined extracts were dried (MgSO4)
9. filtrationfiltered
10. concentrationconcentrated
11. customto give a solid
12. customthe mixture was evaporated to dryness
13. customto give a pink solid which
14. customwas dried in vacuo overnight

ORD record

ord-17f184143f31448d96985b8070da4c75

Source dataset

uspto-grants-2009_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07638631B2