反应详情

To a stirred solution of 18 (2 g, 4.84 mmol), AIBN (0.08 g, 0.48 mmol), Bu3SnH (3.91 ml, 14.50 mmol) in toluene (49 ml) was heated to reflux for 15 h. After cooling, the reaction mixture was evaporated and then extracted by CH2Cl2. The combined organic layer was dried by MgSO4 and concentrated to give a residue that was purified by silica gel flash column chromatography (EtOAc:n-hexane=1:2) to give compound 19, yield 90%.

1. temperatureto reflux for 15 h
2. temperatureAfter cooling
3. customthe reaction mixture was evaporated
4. extractionextracted by CH2Cl2
5. dry with materialThe combined organic layer was dried by MgSO4
6. concentrationconcentrated
7. customto give a residue that
8. customwas purified by silica gel flash column chromatography (EtOAc:n-hexane=1:2)