反应详情

A solution of 3-tert-butyl-2-isopropoxy-6-methyl-5-trimethylsilanylethynyl-benzaldehyde (Intermediate 142, 0.45 g, 1.37 mmol) in methanol (5 mL) and tetrahydrofuran was treated with potassium carbonate (0.2 g, 1.45 mmol) and the resulting reaction mixture was stirred at ambient temperature for 3 h. The reaction mixture was evaporated in vacuo and the residue was extracted with diethyl ether and washed with water and brine. The organic phase was dried, filtered and evaporated in vacuo to afford the title compound (0.35 g, 90%).

1. customthe resulting reaction mixture
2. customThe reaction mixture was evaporated in vacuo
3. extractionthe residue was extracted with diethyl ether
4. washwashed with water and brine
5. customThe organic phase was dried
6. filtrationfiltered
7. customevaporated in vacuo