Imidazole → HCID 18695399, compound

HRID 1870211Notes

Reaction equation

HRID 1870211 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][NH:6][C:7]1[CH:12]=[C:11](F)[C:10]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:9][C:8]=1[N+:22]([O-:24])=[O:23])[CH3:2].[NH:26]1[CH:30]=[CH:29][N:28]=[CH:27]1>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][NH:6][C:7]1[CH:12]=[C:11]([N:26]2[CH:30]=[CH:29][N:28]=[CH:27]2)[C:10]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:9][C:8]=1[N+:22]([O-:24])=[O:23])[CH3:2]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 18695453HCID 18695453, compound

Product 1

HCID 18695399HCID 18695399, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By using 448 mg of N-(4-benzyloxy-5-fluoro-2-nitrophenyl)glycine ethyl ester, 350 mg of imidazole and 2 ml of DMF, 331 mg (65%) of N-[4-benzyloxy-5-(1H-imidazol-1-yl)-2-nitrophenyl]glycine ethyl ester was obtained.

Sources & evidence

ORD record
ord-c52a89114c514965bc9d601b6103e225
Source dataset
uspto-grants-2000_08
Patent number
US06096743

Reaction notes

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