反应详情

To a solution of the title compound of Step B (5.0 g) in p-dioxane (115 mL) at room temperature was added via syringe diphosgene (4.2 mL) followed by the addition of triethylamine (4.8 mL). The mixture was heated at reflux overnight while stirring. The reaction was monitored by IR (2267 cm-1). The reaction mixture was filtered and the residue was washed with diethyl ether. The filtrate was concentrated under reduced pressure to give 5.8 g of the title compound of Step C as a beige solid which was used without further purification.

1. temperatureThe mixture was heated
2. temperatureat reflux overnight
3. filtrationThe reaction mixture was filtered
4. washthe residue was washed with diethyl ether
5. concentrationThe filtrate was concentrated under reduced pressure