Methyl iodide → HCID 18767848, compound

HRID 1870666Notes

Reaction equation

HRID 1870666 reaction equation
CI.[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11](=[O:32])[NH:12][C:13]([CH2:22][CH2:23][CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[N:14][C:15]=2[C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)=[CH:6][CH:5]=1.[C:33](=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11](=[O:32])[N:12]([CH3:33])[C:13]([CH2:22][CH2:23][CH2:24][CH2:25][C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)=[N:14][C:15]=2[C:16]2[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 135703014HCID 135703014, compound

Product 1

HCID 18767848HCID 18767848, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Methyl iodide (22 μl, 0.351 mmol) was added to a stirring mixture of 5-(4-fluorophenyl)-2-(4-phenylbutyl)-6-(4-pyridyl)-4(3 H)-pyrimidinone (140 mg, 0.351 mmol) and potassium carbonate (49 mg, 0.351 mmol) in N,N-dimethylformamide (5 ml). After 75 min, it was evaporated and the resultant product purified on a silica gel column (hexane-acetone=3:1; 2:1) to provide the title compound. MS (m/z): 414.3 (M+H)+ ; C26H24FN3O requir. 413.5.

Workup

  1. customit was evaporated
  2. customthe resultant product purified on a silica gel column (hexane-acetone=3:1; 2:1)

Sources & evidence

ORD record
ord-9f8adbb0e4cc45708e451cb230611c93
Source dataset
uspto-grants-2000_08
Patent number
US06096753

Reaction notes

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