反应详情

A solution of methyl 2-[N-(5-bromo-2-hydroxybenzyl)-N-ethylamino]-5-pyridylcarboxylate (reference example 7) (0.73 g, 2 mM) in DMF (12 ml) was treated with K2CO3 (0.83 g, 6 mM) and 2,3-dichloro-1-propene (0.490 g, 44 mM). The reaction was allowed to stir at ambient temperature for 48 hours. The reaction was evaporated at reduced pressure. The residue was subjected to chromatography (eluant: ethyl acetate/hexane) to give the title compound as a white solid (0.8 g).

1. customThe reaction was evaporated at reduced pressure