Methanesulfonic Acid → HCID 86755585, compound

HRID 1870820Notes

Reaction equation

HRID 1870820 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([C:11]2[CH:15]=[C:14]([N:16]=[C:17]([NH2:24])[N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[O:13][N:12]=2)([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[CH3:31][S:32]([OH:35])(=[O:34])=[O:33]>O1CCOCC1>[CH3:31][S:32]([OH:35])(=[O:34])=[O:33].[F:1][C:2]1[CH:7]=[C:6]([C:8]([C:11]2[CH:15]=[C:14]([N:16]=[C:17]([NH2:24])[N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[O:13][N:12]=2)([CH3:9])[CH3:10])[CH:5]=[CH:4][C:3]=1[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 54257618HCID 54257618, compound

Product 1

HCID 86755585HCID 86755585, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound (1.53 g) obtained in Example 51 was dissolved in 1,4-dioxane and methanesulfonic acid (0.27 ml) was added under ice-cooling, after which the solution was stirred for 30 minutes. Subsequently, it was purified by a recrystallization method from 1,4-dioxane to obtain the desired compound (1.89 g).

Workup

  1. temperaturecooling
  2. customSubsequently, it was purified by a recrystallization method from 1,4-dioxane

Sources & evidence

ORD record
ord-278b02b9c82c4c15bbcda8142576f4a2
Source dataset
uspto-grants-2000_08
Patent number
US06100260

Reaction notes

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