Bromobenzene → HCID 339047, compound

HRID 1870860Notes

Reaction equation

HRID 1870860 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([Li])CCC.[CH3:13][N:14]1[CH:19]2[CH2:20][CH2:21][CH:15]1[CH2:16][C:17](=[O:22])[CH2:18]2>>[CH3:13][N:14]1[CH:19]2[CH2:20][CH2:21][CH:15]1[CH2:16][C:17]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)([OH:22])[CH2:18]2

Participants

4

Reactant 3

HCID 7961BromobenzeneHCID 79038Npc164516HCID 178418339Butyllithium

Product 1

HCID 339047HCID 339047, compound

Procedure

The title compound was prepared from bromobenzene (42.1 mL, 0.4 mol), n-butyllithium in hexanes (156 mL, 2.5 M, 0.39 mol) and 8-methyl-8-azabicyclo[3.2.1]-octan-3-one (25 g, 0.18 mol). Yield 14 g (36%), m.p. 157-159° C.

Sources & evidence

ORD record
ord-ced5be1e975c43838eb928c79f6c66a1
Source dataset
uspto-grants-2000_08
Patent number
US06100275

Reaction notes

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