Hydrochloric Acid → HCID 86752687, compound

HRID 1870959Notes

Reaction equation

HRID 1870959 reaction equation
[C:1]([O:5][C:6]([C:8]1[N:9](C(OC(C)(C)C)=O)[C:10]2[C:15]([C:16]=1[CH:17]([CH:19]1[C:23](=[O:24])[N:22]([C:25](OC(C)(C)C)=O)N(C3C4CC5CC(CC3C5)C4)[CH2:20]1)O)=[C:14]([Cl:42])[CH:13]=[C:12]([Cl:43])[CH:11]=2)=[O:7])(C)(C)C.Cl>C(O)C>[Cl:42][C:14]1[CH:13]=[C:12]([Cl:43])[CH:11]=[C:10]2[C:15]=1[C:16](/[CH:17]=[C:19]1/[C:23](=[O:24])[N:22]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:25][CH2:20]/1)=[C:8]([C:6]([O:5][CH3:1])=[O:7])[NH:9]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18694373HCID 18694373, compound

Product 1

HCID 86752687HCID 86752687, compoundYield 215.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Intermediate 4 (700 mg) was suspended in ethanol (95%) (10 ml), hydrochloric acid (10 ml, 6 M) was added and the heterogeneous mixture refluxed for 10 h. The suspension was cooled to room temperature and the solid filtered, washed with further portions of 6 M hydrochloric acid and finally vacuum dried to yield the title compound (427 mg) as a white solid

Workup

  1. temperaturethe heterogeneous mixture refluxed for 10 h
  2. filtrationthe solid filtered
  3. washwashed with further portions of 6 M hydrochloric acid and finally vacuum
  4. customdried

Sources & evidence

ORD record
ord-3f299e232b1c4b68b1c18b8572318180
Source dataset
uspto-grants-2000_08
Patent number
US06100289

Reaction notes

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