Sodium hydride → 2-(4-(4-(4-chlorophenyl)-1H-imidazol-1-yl) butyl)-1H-iso indol-1,3(2H)-dione

HRID 1871025Notes

Reaction equation

HRID 1871025 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:31])[C:22]1[C:23](=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:24](N)=[O:25]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][N:11]([CH2:16][CH2:17][CH2:18][CH2:19][N:20]3[C:24](=[O:25])[C:23]4[C:22](=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:21]3=[O:31])[CH:12]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 18694800HCID 18694800, compoundHCID 178477960HCID 178477960, compound

Product 1

HCID 702734862-(4-(4-(4-chlorophenyl)-1H-imidazol-1-yl) butyl)-1H-iso indol-1,3(2H)-dioneYield 37.4%

Procedure

Using the procedure of Stage A of Example 1, 12.2 g of the product of Stage A, 4.96 g of sodium hydride and 23.83 g of N-4-bromobutyl-phthalamide were reacted to obtain 9.7 g of the expected product.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d8b05194f7ea40b9bb64723494c8af02
Source dataset
uspto-grants-2000_08
Patent number
US06100404

Reaction notes

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