Hydrazine hydrate (1:1) → 4-(4-chlorophenyl)-1H-imidazol-1-butanamine

HRID 1871026Notes

Reaction equation

HRID 1871026 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][N:11]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]3C(=O)C4C(=CC=CC=4)C3=O)[CH:12]=2)=[CH:4][CH:3]=1.O.NN>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][N:11]([CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH:12]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 702734862-(4-(4-(4-chlorophenyl)-1H-imidazol-1-yl) butyl)-1H-iso indol-1,3(2H)-dione

Product 1

HCID 186947794-(4-chlorophenyl)-1H-imidazol-1-butanamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using the procedure of Stage B of Example 1, 14.2 g of product of Stage B and 3.6 ml of hydrazine hydrate in 200 ml of ethanol were reacted to obtain 12 g of crude product which was chromatographed on silica (eluant CH2Cl2 --MeOH--NH4OH 8-2-0.04) to obtain the expected product, which is used as is for the synthesis.

Workup

  1. customwere reacted
  2. customto obtain 12 g of crude product which
  3. customwas chromatographed on silica (eluant CH2Cl2 --MeOH--NH4OH 8-2-0.04)

Sources & evidence

ORD record
ord-b9d0b149220c478da9722b45aa0f014e
Source dataset
uspto-grants-2000_08
Patent number
US06100404

Reaction notes

Loading…