反应详情

The title compound was prepared according to the procedure in Example 5, step 1 using commercial 2,3-dimethylfuran (5.00 g, 52.0 mmol), commercial 4-bromobenzylbromide (13.0 g, 52.0 mmol) and 2.5M n-BuLi/hexanes (20.8 mL, 52.0 mmol) in THF. Purification on Biotage KP-Sil eluting with 1% EtOAc/pet. ether gave 5.72 g (41%) of the title compound. 1H NMR (DMSO-d6) δ 1.84 (s, 3 H), 2.09 (s, 3 H), 3.83 (s, 2 H), 5.87 (s, 1 H), 7.17 (d, 2 H), 7.49 (d, 2 H).

1. customThe title compound was prepared
2. customPurification on Biotage
3. washKP-Sil eluting with 1% EtOAc/pet. ether