反应详情

温度

90 °C

10.7 g (0.214 mol) of hydrazine hydrate were added in the course of 10 minutes with stirring at 50° C. to 25.0 g (0.102 mol) of 2,5-dichloro-6-methoxy-3-trifluoromethylpyridine in 100 ml of propanol and the mixture was stirred at 90° C. for 3 hours. After cooling, the resulting suspension was added to 1.2 liters of water, the precipitate was filtered off with suction and taken up in methylene chloride, and the solution was washed with water. The organic phase was dried and concentrated, and the residue was stirred with ether/pentane (1:1). After filtering off with suction and drying, 7.8 g (32% of theory) of the title compound of m.p. 140-142° C. were obtained.

1. temperatureAfter cooling
2. filtrationthe precipitate was filtered off with suction
3. washthe solution was washed with water
4. customThe organic phase was dried
5. concentrationconcentrated
6. stirringthe residue was stirred with ether/pentane (1:1)
7. filtrationAfter filtering off with suction
8. customdrying