反应详情

To a solution of the product from step (i) (2.75 g) in ethyl acetate (10 ml) was added 1M ethereal HCl (10 ml). The mixture was stirred for 10 minutes and the precipitate filtered off. This was dissolved in thionyl chloride (20 ml) at 0° C. After 2 hours the mixture was warmed to room temperature. Diethyl ether (100 ml) was added and the precipitate filtered off and used directly in the next step. Yield 1.3 g.

1. filtrationthe precipitate filtered off
2. dissolutionThis was dissolved in thionyl chloride (20 ml) at 0° C
3. additionDiethyl ether (100 ml) was added
4. filtrationthe precipitate filtered off