反应详情

A mixture of the product of step (i) (1.73 g), glycine tert-butyl ester (1.4 g) and N,N-diisopropylethylamine (2.6 ml) in dimethylformamide (20 ml) was stirred at room temperature. After 4 hours, the reaction mixture was partitioned between 2M HCl and ethyl acetate. The organic phase was washed with water, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromatography eluting with 5% ethyl acetate in toluene. Yield 1.5 g.

1. customthe reaction mixture was partitioned between 2M HCl and ethyl acetate
2. washThe organic phase was washed with water
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customPurification
6. washeluting with 5% ethyl acetate in toluene