HCID 57299275, compound → HCID 18689715, compound

HRID 1872001Notes

Reaction equation

HRID 1872001 reaction equation
[CH2:1]([C:3]1[CH:44]=[CH:43][C:6]2[CH:7]([C:17]3[C:18](=[O:42])[NH:19][C:20](=[O:41])[N:21]([C:23]4[N:28]=[C:27]([NH:29][CH2:30][C:31]([O:33]C(C)(C)C)=[O:32])[C:26]([N+:38]([O-:40])=[O:39])=[CH:25][N:24]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]>ClCCl.FC(F)(F)C(O)=O>[CH2:1]([C:3]1[CH:44]=[CH:43][C:6]2[CH:7]([C:17]3[C:18](=[O:42])[NH:19][C:20](=[O:41])[N:21]([C:23]4[N:28]=[C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])[C:26]([N+:38]([O-:40])=[O:39])=[CH:25][N:24]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

Participants

4

Reactant 1

HCID 57299275HCID 57299275, compound

Product 1

HCID 18689715HCID 18689715, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the product from example 28 step (ii) (0.07 g) in dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stirred overnight and evaporated. The residue was triturated with ether and filtered off. Yield 0.05 g.

Workup

  1. customevaporated
  2. customThe residue was triturated with ether
  3. filtrationfiltered off

Sources & evidence

ORD record
ord-8a01ac1f87fd4999806f26c5380aeb5c
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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