P-Cresol → HCID 11708331, compound

HRID 1872432Notes

Reaction equation

HRID 1872432 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14]Cl)=[CH:12][CH:11]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH2:14][C:13]2[CH:16]=[CH:17][C:10]([F:9])=[CH:11][CH:12]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 2879P-CresolHCID 96024-Fluorobenzyl chloride

Product 1

HCID 11708331HCID 11708331, compound

Procedure

Alkylation of 4-methylphenol with 4-fluorobenzyl chloride according to the procedure described in J. Chem. Soc, 2431 (1958) gave 4-methyl-2-(4'-fluorobenzyl)phenol). This material was converted to compound 84 and compound 85 by the procedure similar to that in Example 18 method B.

Sources & evidence

ORD record
ord-16755d5abb894a6fb83a3831bdbd21ea
Source dataset
uspto-grants-2000_08
Patent number
US06107494

Reaction notes

Loading…