反应详情

To a mixture of 78b (160 mg, 0.54 mmol) and anisole (0.1 mL) was added TFA (1.0 mL). The resulting mixture was stirred for 30 min at room temperature, evaporated to dryness and put on vacuum line for 2 hours, and triturated with anhydrous Et2O to give 135 mg of 79b as a semi-solid. This crude product was used directly in the next step without further purification. 1HNMR (300 MHz, CD3OD): δ2.74 (3H, m); 7.55 (2H, t, J=7.8 Hz); 7.69 (1H, t, J=7.5 Hz); 8.02 (2H, d, J=7.5 Hz) ppm. IR (NaCl, film): 3226, 2936, 1695, 1680, 1540, 1188 cm-1.

1. customevaporated to dryness
2. waitput on vacuum line for 2 hours
3. customtriturated with anhydrous Et2O