反应详情

温度

0 °C

A mixture of 3-methylstyrene (1.69 ml, 12.7 mmol), and AD-mix-α (17.78 g, 12.7 mmol) in water (65 ml) and t-BuOH (65 ml) was stirred at 0° C. for 3.5 h. To this reaction mixture was added Na2SO3 (20 g) and the mixture was stirred at rt for 1 h. The reaction mixture was extracted with ethyl acetate. The extract was washed with brine, dried (Na2SO4), and concentrated to give 2.07 g of light brown oil, which was purified by column chromatography (silica gel: 110 g, ethyl acetate/hexane: 3/2) to afford 1.89 g (98%) of desired product as light brown oil.

1. stirringthe mixture was stirred at rt for 1 h
2. extractionThe reaction mixture was extracted with ethyl acetate
3. washThe extract was washed with brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated