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HRID18732

反应详情

EQUATION

反应方程式

HRID 18732 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N1C(NCc2cc(F)c(F)c(F)c2)=N[C@@H](c2ccccc2)[C@H]1c1ccccc1
HCID68568708

未命名化合物

PRODUCTS

生成物

1
结构：Cl.Fc1cc(CNC2=N[C@@H](c3ccccc3)[C@@H](c3ccccc3)N2)cc(F)c1F
HCID68570925

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Hydrogen chloride is bubbled into a solution of 83 (0.44 g, 0.91 mmol) in EtOAc (15 mL) for 1 min, and the solution is stirred at RT overnight. The solvent is removed by rotary evaporation, and the residue crystallized from dichloromethane and Et2O give 0.21 g of the product 84. 1H NMR (DMSO-d6) δ 9.40 (s, 1 H), 9.14 (t, 1 H), 7.88 (s, 1 H), 7.20-6.80 (m, 8 H), 6.80-6.55 (m, 4 H), 5.07 (s, 2 H), 4.70-4.50 (m, 2 H); MS: m/z 382 (M++1).

WORKUP

后处理

  1. customThe solvent is removed by rotary evaporation
  2. customthe residue crystallized from dichloromethane and Et2O