HCID 58151927, compound → HCID 58151932, compound

HRID 1873315Notes

Reaction equation

HRID 1873315 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([CH:13]1[CH2:18][CH2:17][CH:16]([CH2:19][CH2:20][CH3:21])[CH2:15][CH2:14]1)[CH2:6][CH2:7]2>C1COCC1.[Pd]>[F:12][C:11]1[C:2]([F:1])=[C:3]2[C:8]([CH2:7][CH2:6][CH:5]([CH:13]3[CH2:18][CH2:17][CH:16]([CH2:19][CH2:20][CH3:21])[CH2:15][CH2:14]3)[CH2:4]2)=[CH:9][CH:10]=1

Participants

4

Reactant 1

HCID 58151927HCID 58151927, compound

Product 1

HCID 58151932HCID 58151932, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

76.0 g (0.26 mol) of 5,6-difluoro-3-(4-propylcyclohexyl)-1,2-dihydronaphthalene are hydrogenated at RT and atmospheric pressure for 19 h in 500 ml of THF in the presence of Pd/C (5% of Pd). The reaction solution is filtered and evaporated to dryness. The residue is used for the following reaction without further purification.

Workup

  1. customare hydrogenated at RT
  2. filtrationThe reaction solution is filtered
  3. customevaporated to dryness
  4. customThe residue is used for the following reaction without further purification

Sources & evidence

ORD record
ord-560499e664ea49bb9a9f51cff2d506e8
Source dataset
uspto-grants-2012_11
Patent number
US08303844B2

Reaction notes

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