反应详情

34 mg (0.06 mmol) of the compound from Example 24A are dissolved in 1.2 ml of dry DMF, and 17 mg (0.07 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 19 mg (0.23 mmol) of sodium bicarbonate are added. The reaction mixture is stirred at RT for 8 h. The mixture is then filtered, and about 0.5 ml of water is added to the filtrate. The precipitate formed is filtered off with suction and dried under reduced pressure at +50° C.

1. filtrationThe mixture is then filtered
2. additionabout 0.5 ml of water is added to the filtrate
3. customThe precipitate formed
4. filtrationis filtered off with suction
5. customdried under reduced pressure at +50° C.