4-Aminopyridine → HCID 59161030, compound

HRID 1873578Notes

Reaction equation

HRID 1873578 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.Br[C:9]1[N:14]=[C:13]([CH2:15][OH:16])[CH:12]=[CH:11][CH:10]=1>C(#N)C>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:9]2[N:14]=[C:13]([CH2:15][OH:16])[CH:12]=[CH:11][CH:10]=2)=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 17274-AminopyridineHCID 3517811(6-Bromopyridin-2-yl)methanol

Product 1

HCID 59161030HCID 59161030, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1.35 g (14.3 mmol) of 4-aminopyridine and 1.34 g (7.1 mmol) of (6-bromopyridin-2-yl)methanol are stirred at 150° C. for 4 h. After cooling to RT, 50 ml of acetonitrile are added and the reaction mixture is stirred for 20 min. The precipitate formed is filtered off with suction at 0° C. and washed with 10 ml of acetonitrile.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered off with suction at 0° C.
  3. washwashed with 10 ml of acetonitrile

Sources & evidence

ORD record
ord-b5c6e61fd8914dd09e88ce08d61b33b8
Source dataset
uspto-grants-2012_11
Patent number
US08304412B2

Reaction notes

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