Hydrochloric Acid → HCID 24958338, compound

HRID 1873598Notes

Reaction equation

HRID 1873598 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[C:5]([C:23]#[N:24])=[C:4]([S:25][CH2:26][C:27]2[N:28]=[C:29]([NH:32][C:33]3[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=3)[S:30][CH:31]=2)[N:3]=1.Cl>O1CCOCC1>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[C:5]([C:23]#[N:24])=[C:4]([S:25][CH2:26][C:27]2[N:28]=[C:29]([NH:32][C:33]3[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=3)[S:30][CH:31]=2)[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89265164HCID 89265164, compound

Product 1

HCID 24958338HCID 24958338, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

40 mg (0.07 mmol) of the compound from Example 18A are dissolved in 0.9 ml of dioxane, and 0.9 ml of a 4 M solution of hydrogen chloride in dioxane are added. The reaction mixture is stirred at RT for 2 h and then directly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5, 15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

Workup

  1. customdirectly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5, 15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5)

Sources & evidence

ORD record
ord-e34c2828820d444cbb53de4682c22384
Source dataset
uspto-grants-2012_11
Patent number
US08304412B2

Reaction notes

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