3-Isopropoxypropylamine → HCID 86650701, compound

HRID 1873688Notes

Reaction equation

HRID 1873688 reaction equation
Cl.[F:2][C:3]1[CH:24]=[C:23]([NH:25][C:26]([NH:28][C:29](=[O:37])[CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[S:27])[CH:22]=[CH:21][C:4]=1[O:5][C:6]1[C:15]2[C:10](=[CH:11][C:12]([O:19][CH3:20])=[C:13]([C:16](O)=[O:17])[CH:14]=2)[N:9]=[CH:8][CH:7]=1.[CH:38]([O:41][CH2:42][CH2:43][CH2:44][NH2:45])([CH3:40])[CH3:39]>O1CCCC1>[F:2][C:3]1[CH:24]=[C:23]([NH:25][C:26]([NH:28][C:29](=[O:37])[CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[S:27])[CH:22]=[CH:21][C:4]=1[O:5][C:6]1[C:15]2[C:10](=[CH:11][C:12]([O:19][CH3:20])=[C:13]([C:16]([NH:45][CH2:44][CH2:43][CH2:42][O:41][CH:38]([CH3:40])[CH3:39])=[O:17])[CH:14]=2)[N:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 761943-IsopropoxypropylamineHCID 866506984-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylic acid hydrochloride

Product 1

HCID 86650701HCID 86650701, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 1e (13.2 mg), 3-isopropoxypropylamine (9.11 μL), and 4-(5,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholine hydrochloride n-hydrate (hereinafter referred to as DMTMM•n-hydrate) (8.67 mg) were dissolved in tetrahydrofuran (1 mL), followed by stirring at room temperature for 2 hours. The reaction mixture was distilled under reduced pressure, and water was added to the residue. The precipitate was filtrated, to thereby yield the titled compound 1 (11.6 mg, yield: 79%).

Workup

  1. distillationThe reaction mixture was distilled under reduced pressure, and water
  2. additionwas added to the residue
  3. filtrationThe precipitate was filtrated

Sources & evidence

ORD record
ord-2bd0686f474e4bb1b8108ed8b5cda34c
Source dataset
uspto-grants-2012_11
Patent number
US08304427B2

Reaction notes

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