Water → 5-Chloro-3-methyl-2-phenyl-3H-imidazole-4-carbaldehyde

HRID 1873773Notes

Reaction equation

HRID 1873773 reaction equation
[Cl:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:4][C:3]=1[CH:13]=[O:14].CI.[C:17](=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[Cl:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:4]([CH3:17])[C:3]=1[CH:13]=[O:14]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178520008HCID 178520008, compound

Product 1

HCID 866380455-Chloro-3-methyl-2-phenyl-3H-imidazole-4-carbaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1 g (4.8 mmol) of 5-chloro-2-phenyl-3H-imidazole-4-carbaldehyde, 0.824 g (5.8 mmol) of methyl iodide and 1.338 g (9.7 mmol) of potassium carbonate in 50 ml of DMF were stirred at room temperature for 4 h. The reaction mixture was poured onto 200 ml of water, the resulting mixture stirred for 1 h, and the product was filtered off with suction and dried. Yield: 820 mg.

Workup

  1. filtrationthe product was filtered off with suction
  2. customdried

Sources & evidence

ORD record
ord-05d8b7e3119340a3922b0d018119d393
Source dataset
uspto-grants-2012_11
Patent number
US08304438B2

Reaction notes

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