反应详情

温度

50 °C

To a 250 ml round bottom flask was added tert-butyl 4-{1-[(methylsulfonyl)oxy]ethyl}piperidine-1-carboxylate (11 g, 35.8 mmol), 3-(trifluoromethyl)benzenethiol (7.6 g, 43 mmol), K2CO3 (9.9 g, 72 mmol) and 80 ml dimethylformamide. The reaction mixture was heated at 50° C. for 36 hr under N2, then cooled down to room temperature, 150 ml ether was added. The resulting mixture was sequentially washed with 250 ml water, 100 ml 5% KOH solution and 75 ml brine. The organic layers were dried over sodium sulfate, filtered and concentrated to give 13.7 g crude product. It was used for next step without further purification.

1. temperaturecooled down to room temperature
2. washThe resulting mixture was sequentially washed with 250 ml water, 100 ml 5% KOH solution and 75 ml brine
3. dry with materialThe organic layers were dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated