Perchloric Acid → Palonosetron hydrochloride

HRID 1873986Notes

Reaction equation

HRID 1873986 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([N:9]1[CH:18]=[C:17]3[CH2:19][CH2:20][CH2:21][C:15]4[C:16]3=[C:11]([CH:12]=[CH:13][CH:14]=4)[C:10]1=[O:22])[CH2:2]2.[Cl:23](O)(=O)(=O)=O>C(O)(=O)C>[CH:13]1[CH:12]=[C:11]2[C:10]([N:9]([C@H:3]3[CH:4]4[CH2:7][CH2:8][N:1]([CH2:6][CH2:5]4)[CH2:2]3)[CH2:18][C@H:17]3[CH2:19][CH2:20][CH2:21][C:15](=[C:16]23)[CH:14]=1)=[O:22].[ClH:23]

Participants

4

Reactant 2

HCID 24247Perchloric AcidHCID 6101833HCID 6101833, compound

Product 1

HCID 6918303Palonosetron hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Palonosetron hydrochloride was prepared from 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one of formula-H using acetic acid and perchloric acid as reaction solvent

Workup

  1. customas reaction solvent

Sources & evidence

ORD record
ord-62c191e8564a4c989d2c6549676855a8
Source dataset
uspto-grants-2012_11
Patent number
US08304544B2

Reaction notes

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