反应详情

At 5° C. 4-bromobenzylbromide (100 g, 402 mmol) in 100 mL DMF is added to a mixture of dimethylamine (40% in water, 150 mL, 1.33 mol). After 0.5 h stirring at RT, 6 M aqueous HCl is added and the reaction mixture is extracted with diethyl ether. The combined organic phases are washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue is purified by vacuum distillation (bp 58° C. at 2 mbar). Yield: 77.6 g.

1. customAt 5° C
2. extractionthe reaction mixture is extracted with diethyl ether
3. washThe combined organic phases are washed with brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo
6. distillationThe residue is purified by vacuum distillation (bp 58° C. at 2 mbar)