N-Hydroxyphthalimide → HCID 66911105, compound

HRID 1874081Notes

Reaction equation

HRID 1874081 reaction equation
[OH:1][N:2]1[C:6](=[O:7])[C:5]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:4]2[C:3]1=[O:12].C(=O)([O-])[O-].[K+].[K+].Cl.[Cl:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[ClH:20].[N:23]1([CH2:22][CH2:21][O:1][N:2]2[C:3](=[O:12])[C:4]3[C:5](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]2=[O:7])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 10665N-HydroxyphthalimideHCID 11430Potassium CarbonateHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

Product 1

HCID 66911105HCID 66911105, compound

Procedure

B-16a is prepared analogously to B-15a starting from N-hydroxyphthalimide (5.0 g, 30.7 mmol), potassium carbonate (4.24 g, 30.7 mmol) and N-(2-chloroethyl)morpholine hydrochloride (6.27 g, 33.7 mmol). The product is isolated as the hydrochloride. Yield: 4.22 g.

Workup

  1. customB-16a is prepared analogously to B-15a

Sources & evidence

ORD record
ord-b76e9ffb56c149ff82cb6ef39bee052c
Source dataset
uspto-grants-2012_11
Patent number
US08304556B2

Reaction notes

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