tert-Butyl carbazate → HCID 67160005, compound

HRID 1874089Notes

Reaction equation

HRID 1874089 reaction equation
[CH:1]1([N:4]2[CH2:9][CH2:8][C:7](=O)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.[C:11]([O:15][C:16](=[O:19])[NH:17][NH2:18])([CH3:14])([CH3:13])[CH3:12]>C1COCC1>[C:11]([O:15][C:16]([NH:17][N:18]=[C:7]1[CH2:8][CH2:9][N:4]([CH:1]2[CH2:3][CH2:2]2)[CH2:5][CH2:6]1)=[O:19])([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 70091tert-Butyl carbazateHCID 162276291-Cyclopropylpiperidin-4-one

Product 1

HCID 67160005HCID 67160005, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1-cyclopropyl-4-piperidon (10.0 g. 71.8 mmol) and tert-butylcarbazate (9.50 g, 71.8 mmol) in 25 mL THF is stirred for 3 h at RT and then concentrated in vacuo. Yield: 19.2 g.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-a9f6746ddbda4150adca5fb2dd560b26
Source dataset
uspto-grants-2012_11
Patent number
US08304556B2

Reaction notes

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