Hydroxylamine → N'-hydroxy-3-(2-methylpropan-2-ylsulfinamido)-3,3-bis(3-(trifluoromethoxy)phenyl)propanamidine

HRID 1874162Notes

Reaction equation

[C:1]([CH2:3][C:4]([NH:27][S@@:28]([C:30]([CH3:33])([CH3:32])[CH3:31])=[O:29])([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22]C(F)(F)F)[CH:17]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]([F:15])([F:14])[F:13])[CH:6]=1)#[N:2].[NH2:34][OH:35].CO.C(O)([C:40]([F:43])([F:42])[F:41])=O>CCO.O>[OH:35][N:34]=[C:1]([NH2:2])[CH2:3][C:4]([NH:27][S:28]([C:30]([CH3:33])([CH3:32])[CH3:31])=[O:29])([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:40]([F:41])([F:42])[F:43])[CH:17]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]([F:13])([F:15])[F:14])[CH:6]=1

Participants

Conditions

Temperature: 62.5 °C

Procedure

(R)—N-(2-Cyano-1,1-bis(3-(trifluoromethoxy)phenyl)ethyl)-2-methylpropane-2-sulfinamide (140 mg, 0.28 mmol) was stirred in EtOH (3 mL) and NH2OH in H2O (3 mL) in a capped microwave tube. The mixture was heated in an oil bath at 60-65° C. for 2 h. LC-MS (ESI) 528.42 (M+H), retention time=3.46 min (10-90% MeOH in H2O with 0.1% TFA in a 4-min run). The cap was removed and the solvents were concentrated. The residue was dissolved in CH2Cl2, washed with H2O, dried over MgSO4, filtered, and concentrated to give crude N′-hydroxy-3-(2-methylpropan-2-ylsulfinamido)-3,3-bis(3-(trifluoromethoxy)phenyl)propanamidine.

Workup

customThe cap was removed
concentrationthe solvents were concentrated
dissolutionThe residue was dissolved in CH2Cl2
washwashed with H2O
dry with materialdried over MgSO4
filtrationfiltered
concentrationconcentrated

Sources & evidence

ORD record: ord-08955227b9284f0ea1e3f96f0ca286a5
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08304403B2

Reaction notes

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