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HRID18743

反应详情

EQUATION

反应方程式

HRID 18743 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N1C(NC(=O)c2ccc(F)cc2)=N[C@@H](c2ccccc2)[C@H]1c1ccccc1
HCID68569865

未命名化合物

PRODUCTS

生成物

1
结构：Cl.O=C(NC1=N[C@@H](c2ccccc2)[C@@H](c2ccccc2)N1)c1ccc(F)cc1
HCID68567779

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Hydrogen chloride is bubbled into a solution of 125 (123 mg, 0.267 mmol) in EtOAc (20 mL) for 1 min, and the solution is stirred at RT overnight. The solvent is removed by rotary evaporation, and the residue is triturated with Et2O to give 50 mg of the product 126. 1H NMR (DMSO-d6) δ 12.9 (s, 1 H), 9.70 (s, 2 H), 8.35-8.15 (m, 2 H), 7.60-7.40 (m, 2 H), 7.20-6.90 (m, 10), 5.70 (s, 2 H); LC/MS: 3.20 m/z 360 (M++1).

WORKUP

后处理

  1. customThe solvent is removed by rotary evaporation
  2. customthe residue is triturated with Et2O