Water → HCID 57749246, compound

HRID 1874416Notes

Reaction equation

HRID 1874416 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[O:7][C:8]1[CH:9]=[CH:10][C:11]2[N:12]([N:14]=[C:15]([NH2:17])[N:16]=2)[CH:13]=1)([O-:3])=[O:2].[CH:21]1([C:24](Cl)=[O:25])[CH2:23][CH2:22]1.O>CN(C)C(=O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[O:7][C:8]1[CH:9]=[CH:10][C:11]2[N:12]([N:14]=[C:15]([NH:17][C:24]([CH:21]3[CH2:23][CH2:22]3)=[O:25])[N:16]=2)[CH:13]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 962WaterHCID 77637Cyclopropanecarbonyl chlorideHCID 57749222HCID 57749222, compound

Product 1

HCID 57749246HCID 57749246, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

To a solution of 6-(3-nitrophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-amine (3.49 g, 12.9 mmol) in N,N-dimethylacetamide (20 mL) was added with stirring under ice-cooling cyclopropanecarbonyl chloride (2.46 mL, 27.0 mmol), and the mixture was stirred at room temperature for 15 hr. Water (40 mL) was added to the reaction mixture, and the precipitated solid was collected by filtration, washed with water and dried to give the title compound (3.86 g, 88%) as a white solid.

Workup

  1. stirringthe mixture was stirred at room temperature for 15 hr
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-62cbe8365fa2471ebd422cfdbda680da
Source dataset
uspto-grants-2012_11
Patent number
US08304557B2

Reaction notes

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