HCID 57749407, compound → N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

HRID 1874459Notes

Reaction equation

HRID 1874459 reaction equation
[CH:1]1([C:4]([NH:6][C:7]2[N:31]=[C:10]3[CH:11]=[CH:12][C:13]([O:15][C:16]4[CH:17]=[CH:18][C:19]([CH3:30])=[C:20]([NH:22]C(=O)OC(C)(C)C)[CH:21]=4)=[CH:14][N:9]3[N:8]=2)=[O:5])[CH2:3][CH2:2]1>FC(F)(F)C(O)=O>[NH2:22][C:20]1[CH:21]=[C:16]([CH:17]=[CH:18][C:19]=1[CH3:30])[O:15][C:13]1[CH:12]=[CH:11][C:10]2[N:9]([N:8]=[C:7]([NH:6][C:4]([CH:1]3[CH2:3][CH2:2]3)=[O:5])[N:31]=2)[CH:14]=1

Participants

3

Reactant 1

HCID 57749407HCID 57749407, compound

Product 1

HCID 57749401N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamideYield 89%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

In the same manner as in Example 29 and using tert-butyl [5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]carbamate (3.78 g, 8.48 mmol) and trifluoroacetic acid (20 mL) as starting materials, the title compound (2.43 g, 89%) was obtained as a white solid.

Sources & evidence

ORD record
ord-f6a279f9f3684eb89e6c0f0acc2b784e
Source dataset
uspto-grants-2012_11
Patent number
US08304557B2

Reaction notes

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