Cyclopropanecarbonyl chloride → HCID 57749388, compound

HRID 1874509Notes

Reaction equation

HRID 1874509 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[O:7][C:8]1[CH:13]=[CH:12][N:11]2[N:14]=[C:15]([NH2:17])[N:16]=[C:10]2[CH:9]=1)([O-:3])=[O:2].[CH:21]1([C:24](Cl)=[O:25])[CH2:23][CH2:22]1>CN(C)C(=O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[O:7][C:8]1[CH:13]=[CH:12][N:11]2[N:14]=[C:15]([NH:17][C:24]([CH:21]3[CH2:23][CH2:22]3)=[O:25])[N:16]=[C:10]2[CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 57749227HCID 57749227, compound

Product 1

HCID 57749388HCID 57749388, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In the same manner as in Example 18-2 and using 7-(3-nitrophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-amine (112 mg, 0.413 mmol), cyclopropanecarbonyl chloride (135 μL, 0.496 mmol) and N,N-dimethylacetamide (5 mL) as starting materials, the title compound (134 mg, 96%) was obtained as a white solid.

Sources & evidence

ORD record
ord-5eb066f9d6c64770b60196bd7ad3503b
Source dataset
uspto-grants-2012_11
Patent number
US08304557B2

Reaction notes

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