Diisopropylethylamine → HCID 59451423, compound
Reaction equation
[NH2:1][CH2:2][C:3]1[C:4]([F:20])=[C:5]([O:10][C:11]2[CH:12]=[C:13]([CH:16]=[C:17]([Cl:19])[CH:18]=2)[C:14]#[N:15])[C:6]([Cl:9])=[CH:7][CH:8]=1.CCN(C(C)C)C(C)C.[C:30]1([C:36]2[N:37]=[N:38][S:39][C:40]=2[C:41](O)=[O:42])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C.CO>[Cl:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][NH:1][C:41]([C:40]2[S:39][N:38]=[N:37][C:36]=2[C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)=[O:42])=[C:4]([F:20])[C:5]=1[O:10][C:11]1[CH:12]=[C:13]([C:14]#[N:15])[CH:16]=[C:17]([Cl:19])[CH:18]=1Participants
7
Reactant 4
HCID 81531Diisopropylethylamine
HCID 27371674-phenyl-1,2,3-thiadiazole-5-carboxylic acid
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 594513923-{[3-(Aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrileProduct 1
Reagents, catalysts & solvents 2
Procedure
In a 1 dram vial, 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (25 mg, 0.080 mmol), DIPEA (0.014 mL, 0.080 mmol) and 4-phenyl-1,2,3-thiadiazole-5-carboxylic acid (16.57 mg, 0.080 mmol) were dissolved in DMF (1 mL). HATU was added (30.6 mg, 0.080 mmol) and the solution stirred overnight. The reaction mixture was diluted to 2 mL with MeOH. Purification was accomplished by Reverse-Phase HPLC (water/acetonitrile with 0.1% TFA) to afford the title compound (0.015 g, 35%) as a tan solid. 1H NMR (400 MHz, Acetone-d6): 6 ppm 8.51 (br. s., 1H), 7.80-7.90 (m, 2H), 7.63 (t, 1H), 7.45-7.51 (m, 3H), 7.38-7.45 (m, 2H), 7.33-7.38 (m, 2H), 4.65 (d, 2H). LCMS m/z 498.9 (M+1).
Workup
- customPurification
Sources & evidence
- ORD record
- ord-b39ddfa36eac4f618c9e2539e9c1c51e
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08304419B2
Reaction notes
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