Lithium Hydroxide → HCID 68487214, compound

HRID 1874986Notes

Reaction equation

HRID 1874986 reaction equation
[CH3:1][Si:2]([CH3:21])([CH3:20])[CH2:3][CH2:4][O:5][CH2:6][N:7]1[C:11]2[CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[NH:14][C:10]=2[N:9]=[CH:8]1.[Li+].[OH-]>C1COCC1.CO>[CH3:1][Si:2]([CH3:21])([CH3:20])[CH2:3][CH2:4][O:5][CH2:6][N:7]1[C:11]2[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[NH:14][C:10]=2[N:9]=[CH:8]1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 68484667HCID 68484667, compound

Product 1

HCID 68487214HCID 68487214, compoundYield 153.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

Ethyl 1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1,4-dihydropyrrolo[2,3-d]imidazole-5-carboxylate (0.088 g, 0.284 mmol) was dissolved in THF and MeOH. LiOH (1 mL, 1 mmol) was added to the solution and the reaction was heated to 60° C. When starting material was no longer evident by TLC the reaction was evaporated to afford the title compound (0.123 g, 77%) a white solid. This was used with no further purification. LCMS: m/z=280.0 (M−1).

Workup

  1. customwas evaporated

Sources & evidence

ORD record
ord-e6a1a823966f4b5ebdf04be4a52c0206
Source dataset
uspto-grants-2012_11
Patent number
US08304419B2

Reaction notes

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